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NPC Rapid Review Ezetimibe: room for review? Rapid reviews | Podcasts | Shared practice examples | Events | Publications and resources | FAQs | Email alerts | Newsroom | Contact us | A to Z *Note: The MHRA has advised that the black triangle (�) refers to intensive monitoring being requested only when simvastatin is used in children and adolescents (10�17 years), in line with the recently licensed paediatric dosing recommendation.The NICE implementation costing statement estimated that the primary hypercholesterolaemia guidance would result in an additional 1,400 people receiving ezetimibe monotherapy at an additional annual cost of ?260k and that potential increased use of ezetimibe in combination with a statin would be unlikely to have a significant resource impact on the NHS. However, prescribing data suggests that ezetimibe is being used well in excess of that anticipated by NICE following implementation of this guidance. Ezetimibe Reviews Ratings at Drugs.com A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Advanced Phonetic I have used this at 1/2 the prescribed dosage for over a year. My cholesterol levels have improved dramatically even at the lower dosage. I do not believe my cholesterol is a problem but have succumbed to my doctor. I would not take statins although my insurance company says I should. I am pleased with the results. Ezetimibe/simvastatin Reviews Ratings at Drugs.com A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Advanced Phonetic Vytorin is working wonders for me. Finding the right cholesterol lowering medicine was the key. Lipitor gave me the leg cramps, Zocor was good, but did not lower my numbers well enough. Same for Pravachol. On Vytorin, my liver numbers are good. I have not experienced any negative side effects and my numbers are excellent.Everyone in my family has exceptionally high cholesterol, in the 370 range. We produce it. Don't let anyone tell you that you have a bad diet if your cholesterol is high. It is produced by the body and in some people, apparently including me, reduced cholesterol intake results in increased cholesterol production. For several years I was on Lipitor; it never lowered my cholesterol reading below 280. I've used Vytorin 10-40 for probably eight years with no ill side effects. Vytorin took it down to 170 or less. The government contends Vytorin is no more effective than anything else in lowering cholesterol. They've never tested me, of course. Now, because of the government's position, I find Vytorin dropped from my Medicare plan. I'm switching.NPC Rapid Review Ezetimibe� doesn t ENHANCE statins Rapid reviews | Podcasts | Shared practice examples | Events | Publications and resources | FAQs | Email alerts | Newsroom | Contact us | A to Z The NICE technology appraisal on ezetimibe� in hypercholesterolaemia states that ezetimibe� may be used in combination with a statin in limited circumstances in adults with primary hypercholesterolaemia. This option should be considered the results should, in our view, strengthen support for a very cautious approach to using ezetimibe� as discussed in a previous NPC blog. There are difficulties in doing research which will unequivocally demonstrate that ezetimibe� will reduce cardiovascular events because comparison with placebo will usually be unethical.
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